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BMB PhD Program Faculty

Sabra L. Klein

Sex differences & pregnancy effects on immune response

Professor

Department of Molecular Microbiology and Immunology
Bloomberg School of Public Health

Sabra Klein

Research Overview

The overarching goal of our research is to uncover the mechanisms mediating sex differences and the effects of pregnancy on immune responses to microbial infection and vaccination. Our data point to sex steroids signaling through sex steroid receptors as critical pathways modulating immune responses to infection and vaccination. We work with microbes, including influenza, Zika, and SARS-CoV-2 viruses as well as TB and malaria. Our group works with human samples, animal models, and cell culture systems. Trainees learn state-of-the-art immunological, microbiological, and genetic methods along with experimental design, statistical analyses, writing, and presentation skills.

 

 

Topic Areas

Selected Publications

  • Creisher PS, Perry JL, Zhong W, Lei J, Mulka KR, Ryan WH, Zhou R, Akin EH, Liu A, Mitzner W, Burd I, Pekosz A, Klein SL.  Journal of Clinical Investigations, 2023.
  • Ursin RL, Dhakal S, Liu H, Jayaraman S, Park HS, Powell HR, Sherer ML, Littlefield KE, Fink AL, Ma Z, Mueller AL, Chen AP, Seddu K, Woldetsadik YA, Gearhart PJ, Larman HB, Maul RW, Pekosz A, Klein SL.  mBio, 2022.
  • Shapiro JR, Sitaras I, Park HS, Aytenfisu TY, Caputo C, Li M, Lee J, Johnston TS, Li H, Wouters C, Hauk P, Jacobsen H, Li Y, Abrams E, Yoon S, Kocot AJ, Yang T, Huang Y, Cramer SM, Betenbaugh MJ, Debes AK, Morgan R, Milstone AM, Karaba AH, Pekosz A, Leng SX, Klein SL.  Clinical Infectious Diseases, 2022.
  • Klein SL, Pekosz A, Park HS, Ursin RL, Shapiro JR, Benner SE, Littlefield K, Kumar S, Naik HM, Betenbaugh M, Shrestha R, Wu AA, Hughes RM, Burgess I, Caturegli P, Laeyendecker O, Quinn TC, Sullivan DJ, Shoham S, Redd AD, Bloch EM, Casadevall A, Tobian AAR. Journal of Clinical Investigation, 2020.
  • Potluri T, Fink AL, Sylvia KE, Dhakal S, Vermillion MS, Vom Steeg L, Deshpande S, Narasimhan H, Klein SL. NPJ Vaccines, 2019.