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BMB PhD Program Faculty

Chi Van Dang

Oncogenic alteration of metabolism and immunity

Bloomberg Distinguished Professor of Cancer Medicine 

Department of Oncology , School of Medicine
Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health

Chi Van Dang

Research Overview

The Dang lab contributed to defining the function of the MYC oncogene including establishing the first mechanistic link between MYC and cellular energy metabolism. This foundational concept that genetic alterations in cancers re-program fuel utilization by tumors provides a framework to develop novel strategies for cancer therapy. Current lab interests include seeking metabolic and dietary vulnerabilities of cancer and define how MYC and the circadian molecular clock influences cancer immunity, tumorigenesis and therapeutic resistance. The molecular and metabolic basis for T cell function and pancreatic cancer cell immune evasion is an ongoing area of investigation

Additional Titles

CEO & Scientific Director, Ludwig Institute for Cancer Research

 

 

Topic Areas

Selected Publications

  • Brooks R, Monzy J, Aaron B, Zhang X, Kossenkov A, Hayden J, Keeney F, Speicher DW, Zhang L, Dang CV.  Cell Reports, 2022. 
  • Wolpaw AJ, Grossmann LD, Dessau JL, Dong MM, Aaron BJ, Brafford PA, Volgina D, Pascual-Pasto G, Rodriguez-Garcia A, Uzun Y, Arsenian-Henriksson M, Powell DJ Jr, Bosse KR, Kossenkov A, Tan K, Hogarty MD, Maris JM, Dang CV.  PNAS, 2022.
  • Gouw AM, Margulis K, Liu NS, Raman SJ, Mancuso A, Toal GG, Tong L, Mosley A, Hsieh AL, Sullivan DK, Stine ZE, Altman BJ, Schulze A, Dang CV, Zare RN, Felsher DW.  Cell Metabolism, 2019.
  • Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, Zhang L, Powell JD, Dang CV.  Cell, 2018.
  • Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, Maris JM, Felsher DW, Hogenesch JB, Weljie AM, Dang CV.  Cell Metabolism, 2015.

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