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Reforms to the sales practices of a gun store—which prior to May 1999, sold more than half of the guns recovered from criminals in the Milwaukee—resulted in a 44 percent decrease in the flow of new guns to criminals in the city, according to a new study from researchers with the Johns ÎÚÑ»´«Ã½â€™s Center for Gun Policy and Research.

Researchers from the Johns Hopkins University and other institutions have developed a new prediction model for genetic defects known as Lynch syndrome, which predisposes families to develop colorectal cancer. The model, called MMRpro, is based on an individual’s detailed family history of colorectal and endometrial cancer, as well as knowledge of how genetic mutations manifest themselves—in the form of tumors. It can assess a person’s probability of carrying a particular defect within so-called mismatch repair genes.

Johns Hopkins University researchers and colleagues today published an article in JAMA introducing a prediction tool, called MMRpro, which identifies families with genetic defects that cause an increased risk of colorectal cancer. This assessment helps families make decisions about cancer prevention screenings.

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