Departmental Affiliations
Center & Institute Affiliations
Shyam Biswal, PhD, studies the mechanisms by which environmental factors drive chronic health conditions such as diabetes and cardiovascular diseases.
Research Interests
Environmental Health Sciences; Electronic Cigarettes;Cigarette Smoke;Lung diseases;Inflammation;Cancer;COPD;Emphysema;Asthma
Additional Links
Experiences & Accomplishments
See details in Research Program page
http://ehe.jhu.edu/research/faculty-research-interests/biswal/index.html
Select Publications
Selected publications
Rajagopalan S, Park B, Palanivel R, Vinayachandran V, Deiuliis JA, Gangwar RS, Das L, Yin J, Choi Y, Al-Kindi S, Jain MK, Hansen KD, Biswal S. Metabolic effects of air pollution exposure and reversibility. J Clin Invest. 2020 Oct 12:137315. doi: 10.1172/JCI137315. Epub ahead of print. PMID: 32780721.
Kim JH, Thimmulappa RK, Kumar K, Cui W, Kumar S, Kombairaju P, Gaiano N, Zhang H, Margolick J, Matsui W, Macvittie T, Malhotra SV, Biswal S. NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation. J Clin Invest. 2014;3;124(2):730-41.
Singh A, Happel C, Manna SK, Acquaah-Mensah G, Carrerero J, Kumar S, Nasipuri P, Wakabayashi N, Dewi R, Boros LG, Gonzalez FJ, Gabrielson E, Wong KK, Girnun G, Biswal S. Nrf2 regulates miR-1 and miR-206 to drive Tumorigenesis. J Clin Invest. 2013;123 (7) 2921-2934.
Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman JG, Baylin SB, Sidransky D, Gabrielson E, Brock MV, Biswal S. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS medicine. 2006; 3(10):e420.
Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, Sathirapongsasuti JF, Cervo M, Yao H, Chung AL, Harvey C, Thimmulappa R, Sethi S, Kong X, Yarmus L, Brown R, Feller-Kopman D, Wise R, and Biswal S. (2011) Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model. Sci Transl Med 3(78):78ra32.